Research Projects – Advancing Knowledge Together
The development of diagnostic standards begins with research – and this is precisely where CEBIO is active. Together with academic institutions, laboratories, clinics, and industry partners, we carry out scientifically grounded and practice-relevant projects that make molecular diagnostics more reliable, comparable, and compliant with regulatory standards.
Our focus areas include key topics such as liquid biopsy, protein analytics, cfDNA reference materials, and the analytical validation of molecular assays. Our projects are characterized by methodological depth, structured study designs, biological relevance, and a consistent transfer of results into clinical and diagnostic application.
Our Research Focus Areas
- Liquid Biopsy Research Optimization of pre-analytical processes, molecular assays, and bioinformatics workflows for highly sensitive and reproducible analysis of circulating tumor DNA.
- Method Evaluation & Quality Assurance Statistical assessment of diagnostic procedures in the context of feasibility analyses, validation studies, and quality assurance – aligned with IVDR requirements and clinical application.
- Translational Clinical Biomarker Studies Implementation of translational biomarker studies within randomized controlled trials, including pre-analytically standardized sample collection and biobanking, high-quality laboratory analyses, and statistical evaluation with validated final reports – a complete biomarker study service from a single source.
- Development of Reference Materials We produce cell-based, biologically authentic cfDNA materials ideally suited for test development, method validation, and quality assurance. Our approach follows internationally established standards to ensure high comparability and reproducibility.
- Interlaboratory Comparison Studies Design and evaluation of interlaboratory studies to assess method robustness, detection limits, and interlaboratory variance – often based on standardized cfDNA samples.
Scientifically Visible – Internationally Connected
The results of our research are regularly published in scientific journals and professional articles – for example, on the analytical validation of cfDNA NGS tests, evaluation of reference samples in proficiency testings, standardization of diagnostic workflows in liquid biopsy, and translational biomarker studies.
CEBIO has contributed as a co-author or methodological partner to numerous national and international publications in areas such as:
- cfDNA characterization and reference material validation
- Clinical studies on liquid biopsy testing in solid tumors
- Clinical evaluation of multiple biomarkers in translational studies
- Multicenter NGS ring trials
- Sensitivity and specificity analyses of molecular assays
- Quality assurance in interdisciplinary diagnostic projects
These activities highlight our mission: to develop scientifically robust, regulatory-compliant, and clinically applicable diagnostic solutions.
Why CEBIO?
In Short:
CEBIO designs, supports, and analyzes research projects at the interface of molecular diagnostics, quality standards, and clinical practice.
With a special focus on liquid biopsy, reference materials, and interlaboratory comparison studies, we deliver reliable data, establish new standards, and create the foundation for modern, reproducible, and future-proof diagnostics.
